|Graduate School of Science||Chemistry||Professor|
Chemical Biology of DNA
Overview of your research
Professor Sugiyama's research interests involve the bioorganic chemistry of nucleic acids. Using the tools of synthetic physical organic chemistry and molecular biology, the Sugiyama group is defining the chemical principles underlying the recognition, reactivity and structure of nucleic acids. There are no other research groups on such a general and fundamental aspect of nucleic acids as a substance.The group utilizes a chemical approach in following areas: Molecular mechanism of DNA modification by DNA base alkylation, hydrogen abstraction and charge transfer. Design of highly efficient sequence-specific DNA acting agents based on understanding of the action mechanism of antitumor antibiotics. Design of unnatural nucleic acid for understanding of nucleic acid structure and function. Development of a method probing DNA local conformation in vivo. The long-range goal is creation of artificial genetic switches for targeted cell differentiation and treatment of many diseases.
Fields of research (key words)