|Graduate School of Science||Biological Sciences||Assistant Professor|
Visualization of molecular mechanism of learning and memory
Overview of your research
When we learn and remember something, the efficacy of information transmission between neurons change in the brain. The information transmission occurs at a synapse, where a presynaptic neuron secretes transmitter molecule such as glutamate, and receptor proteins on the postsynaptic membrane capture transmitter and respond. Repeated use of a synapse increases the transmission efficacy for long-term, which is called long-term potentiation (LTP), and contributes to the formation of learning and memory. The increase in number of AMPA-type glutamate receptor (AMPAR) is a main molecular mechanism for LTP. However, when and how different types of AMPAR increase in the postsynaptic membrane has been unclear. Therefore, we address this issue by developing new experimental methods to visualize the change and movement of AMPAR around postsynaptic membrane using total internal reflection fluorescence microscopy.
Fields of research (key words)
Synaptic plasticity, Long-term potentiation, AMPA-type glutamate receptor, Total internal reflection fluorescence microscopy, Synapse formation